Yes, but you need foundational prerequisites. Most STEM majors require Calculus, Physics, and Chemistry, if your Class 12 lacks these, you may take them in college (extends time/cost) or self-study for AP exams. Selective STEM programs (MIT, Caltech, CMU CS) expect competitive STEM coursework/scores, so Commerce students should demonstrate math strength through SAT Math Level 2, calculus, or online courses.